| Date | Location | Result | |
| 4/30/2022 | Aston, Pa. | Neumann 15, Gwynedd Mercy 11 | Box score |
| 4/27/2022 | Washington, D.C. | Marymount (Va.) 23, Gwynedd Mercy 13 | Box score |
| 4/23/2022 | Gwynedd Valley, Pa. | Cabrini 21, Gwynedd Mercy 7 | Box score |
| 4/20/2022 | Gwynedd Valley, Pa. | Marywood University 14, Gwynedd Mercy 13 | Box score |
| 4/13/2022 | Aston, Pa. | Gwynedd Mercy 16, Neumann 13 | Box score |
| 4/9/2022 | Immaculata, Pa. | Immaculata 20, Gwynedd Mercy 10 | Box score |
| 4/6/2022 | Towson, Md. | Gwynedd Mercy 13, Goucher 10 | Box score |
| 3/30/2022 | Gwynedd Valley, Pa. | Ursinus College 21, Gwynedd Mercy 7 | Box score |
| 3/23/2022 | Glenside, Pa. | Arcadia University 14, Gwynedd Mercy 7 | Box score |
| 3/19/2022 | Gwynedd Valley, Pa. | Hood 18, Gwynedd Mercy 9 | Box score |
| 3/16/2022 | Gwynedd Valley, Pa. | Gwynedd Mercy 21, Rutgers-Camden 7 | Box score |
| 3/9/2022 | Sewanee, Tenn. | Gwynedd Mercy 25, Saint Mary's College 14 | Box score |
| 3/6/2022 | Sewanee, Tenn. | Sewanee 21, Gwynedd Mercy 10 | Box score |
| 3/2/2022 | Gwynedd Mercy, Pa. | Gwynedd Mercy 21, Wilkes 7 | Box score |
| 2/26/2022 | Gwynedd Valley, Pa. | Gwynedd Mercy 19, Keystone 6 | Box score |
| 2/23/2022 | Gwynedd Valley, Pa. | Gwynedd Mercy 19, Delaware Valley Univ 5 | Box score |
| 2/19/2022 | Reading, Pa. | Alvernia 17, Gwynedd Mercy 10 | Box score |
| 2/16/2022 | Wilkes Barre, Pa. | Gwynedd Mercy 15, King's College (PA) 4 | Box score |